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The risk of opioid-related overdose or overdose-related death is increased with higher opioid doses, and this risk persists over the course of therapy

High-dose supplements may also interact with medications or produce adverse effects

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That pharmacokinetic difference is the foundation for everything the literature documents about its downstream effects, from receptor activation patterns to the study timelines researchers use to observe change

Impaired DNA repair : Lower NAD+ weakens PARP activity, which we need to fix DNA