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When you swallow a B12 pill, several steps have to work for it to be absorbed: stomach acid and the enzyme pepsin must release B12 from food or the supplement, the stomach must secrete a protein called intrinsic factor that binds to B12, and the B12-intrinsic factor complex must reach the ileum (the end of the small intestine) where it is finally absorbed

This is important during atopic dermatitis therapy because their stimulation increases the production of B, T, and NK lymphocytes, which leads to the restoration of balance between T lymphocytes and consequently alleviates the symptoms of atopic dermatitis, including excessive keratinization and lichenification resulting from intense itching

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