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Nasal spray provides systemic distribution that may dilute effects at a specific location

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Abou Zaid ES, Mansour SZ, El-Sonbaty SM, Moawed FS, Kandil EI, Haroun RA

Genetic predispositions affecting microbiota diversity or bile acid transformation can disrupt this balance, promoting inflammation and impaired bile acid recycling

109 In the last 15 years, knowledge on the efficacy and toxicity of the TNFi has been published and was mainly gathered through regional or national registries created after these drugs reach the market