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Both FA and VB 12 are important regulators of DNA methylation and play an important role in early life development ( 12 changes the methylation status of genes associated with offspring growth ( IGF2 ), metabolism ( RXRA ), and appetite control ( LEP ) through consumption of methyl donors, ultimately affecting offspring health ( LEP produces the hormone leptin, which is involved in regulating energy metabolism, making the children eat less, increasing energy release, and inhibiting fat cell synthesis to lose weight ( LEP gene promoter sequence in the cord blood of obese children showed a hypomethylated state ( Vldlr gene and the demethylation of Hif1 gene

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