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The breakdown process of BCAAs is similar in all species, initially forming branched-chain -keto acids (BCKAs) via branched-chain amino acid transferase (BCATs) and transferring nitrogen to nitrogen receptors (the most common nitrogen receptor is -ketoglutaric acid (-KG) to form glutamate)

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Curcumin could regulate multiple signal transduction pathways in experimental UC, including TLR/major myeloid differentiation response gene 88 (MyD88), JAK1/STAT3/SOCS, and TLR4/NF-B/ activating protein (AP)-1, exhibiting anti-inflammatory, immunomodulatory and other effects [242, 261,262,263,264,265]