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the addition of 25 mg/kg curcumin to 200 mg/kg NAC protected rat liver and kidney from acetaminophen toxicity with an efficacy equivalent to 800mg/kg of NAC (Kheradpezhouh 2010)

2.5.1 Lipidperoxidation byproducts Quantification of malondialdehyde (MDA) and 4hydroxynonenal (4HNE) in bronchoalveolar lavage fluid (BALF) or exhaled breath condensate provides a direct readout of membrane lipid damage ( 2.5.2 Enzymatic and protein markers GPX4 activity or expression can be measured by ELISA or immunohistochemistry on BALF cells or transbronchial biopsies

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1 Mechanistically, treatment raised the Bcl-2/Bax ratio and reduced apoptosis markers (cleaved caspase-3 and PARP) in the dermal papilla cells, elevated VEGF production, and decreased TGF-1 secretion from dermal fibroblasts