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Doctors can reduce doses, increase intervals, or change ingredients to ensure safety
However, the effect of NSAIDs on lower esophageal sphincter and pyloric sphicter pressure is far less studied, and is inconsistent and not fully described (16-23)
How TNF- changes in peritoneal fluid tie in with endometriosis phenotypes and menstrual phases was unclear, with reported increases in both stages I/II and III/IV [32], only in stage III/IV with no difference between proliferative and secretory phases, or only in patients with endometrioma and in proliferative phase [135] some of which may reflect inappropriate statistical power to control for Type II errors when stratifying cohorts
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Initial doses may work better with earlier administration, while established protocols tolerate closer-to-bedtime dosing
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