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Lineage-specific profiling delineates the emergence and progression of naive pluripotency in mammalian embryogenesis

Rice is also the surgical PI on a prospective randomized trial to evaluate the hemostatic effects of aprotinin during extrapleural pneumonectomy

[7] Use during pregnancy is contraindicated due to the risk of birth defects

When free iron is present, GPX4 can catalyze the reduction of lipid hydrogen peroxide to nonreactive lipid alcohol and prevent the Fenton reaction of lipid hydrogen peroxide [5]

Under conditions of chronic stress or systemic inflammation, enzymes such as indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) are upregulated, diverting TRP metabolism away from 5-HT synthesis toward KYN production, with profound consequences for both peripheral physiology and central nervous system (CNS) function