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Moreover, the TLR7/8 agonist R848 resensitized colorectal cancer cells to oxaliplatin chemotherapy by reversing oxaliplatin-suppressed differentiation of MDSCs into M1 macrophages, highlighting R848 as an immuno-active adjuvant in chemo-refractory colorectal cancer (156)

Tian, Y., Zeng, H., Xu, Z., Zheng, B., Lin, Y., Gan, C., & Lo, Y

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(64) indicated that eNOS is upregulated in human mesenchymal CRC tumors and may represent an active stem-cell regulatory point in cancer and a possible target for therapy against aggressive human tumors (63, 64)

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