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Further analyses of iron ion levels and the lipid peroxidation markers GSH and MDA revealed that Fe 2+ and MDA levels were significantly higher following PE treatment relative to levels in control cells, while GSH levels were significantly reduced, and PQQ treatment significantly reversed all three of these PE-induced changes (Figures 4BD)

Its ability to cross the blood-brain barrier means it plays an important role in helping remove toxins, such as mercury, from the brain and other cells

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doi: 10.1038/s41420-024-01906-7 40 XuWWangJXuJLiSZhangRShenCet al

Moreover, the lack of large-scale, longitudinal clinical trials using skin-specific endpointssuch as TEWL, AMP expression, and histological markers of epidermal aginghampers the translational application of Vitamin D in anti-aging dermatology