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Therefore, intracellular GSH depletion or GPX4 inactivation induced by various factors will decrease the clearance rate of toxic lipid peroxides and result in ferroptosis

Natural production of CoQ10 can decrease with age and lifestyle factors like diet and smoking, and when CoQ10 levels diminish, we tend to see poorly functioning mitochondria and increased free radical damage which is now known to contribute to a whole host of health issues

J Pharmacol Exp Ther 1995;272:417422