Nature 2009;460, 392-395, doi:10.1038/nature08221
Primarily, sEH inhibitors exert anti-inflammatory activity by preserving the levels of both -6 and -3 epoxy fatty acids including epoxyeicosatrienoic acids (EETs) which are metabolized by sEH (Morisseau and Hammock, 2013)
Exp Mol Med 50 , 116 (2018)
No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
A 35 Ultra Semi diamond knife (Diatome) mounted on a UC7 ultramicrotome (Leica) was used to cut alternating series of sections onto formvar-coated copper mesh grids at two different thicknesses: (i) 60 nm-thick sections were visually inspected to assess ultrastructural preservation and synapse density under an 80kV LEO 912 transmission electron microscope (Zeiss), and (ii) 250 nm-thick sections were coated on both surfaces with Protein A-conjugated 10 nm gold fiducial particles (Cell Microscopy Core Products, University Medical Center Utrecht, The Netherlands) in preparation for transmission electron tomography
