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Beyond its initial recognition as a neuroprotective agent, Humanin has demonstrated cytoprotective effects in various cell types, including cardiomyocytes, neurons, and endothelial cells (Chai et al., 2019)

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Online, it is frequently described as a healing peptide that may help repair tendons, ligaments, muscles, and the gastrointestinal tract

Similarly, in dogs with IBD compared with normal controls, the expression of the protein E-cadherin was lower in the villus epithelium, suggesting the role of this protein in the pathogenesis of IBD in dogs [80]