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In several groups of workers regularly exposed to airborne heavy metal toxicity due to the nature of their work, daily supplementation with 800 mg vitamin E and 500 mg vitamin C for six months led to improved markers of intrinsic antioxidant defenses and decreased markers of oxidative damage

Activator Protein 1 AP-1 is a redox-sensitive transcription factor that regulates gene expression in response to various stimuli, including cytokines, growth factors, and cellular stress

Typical protocols involve doses ranging from 13 mg daily or several times per week, often cycled in 812 week intervals with breaks to prevent receptor downregulation or potential copper accumulation

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