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Gydesen S, Andreassen KV, Hjuler ST, et al

Sleep disruption, stress, and overtraining also contribute

These medications work by slowing down digestion, reducing appetite, and helping the body use insulin more effectively

Topical applications may show initial improvements in skin texture and hydration within 2-4 weeks, with more significant changes in collagen production and skin firmness becoming apparent after 8-12 weeks of consistent use

Clinical observations show tesofensine treatment improves lipid profiles, with reductions in total cholesterol and low-density lipoprotein (LDL) cholesterol levels