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Aptamers have different advantages over antibodies, including much smaller size (making them more appropriate to penetrate solid tumors), less immunogenicity (reducing resistance to treatment), the capability to manipulate their length and physicochemical properties (making them possible to change the half-life, pH sensitivity, flexibility, and conjugation capacity), fast and simple production procedure, negligible inter-batch variation, and better temperature resistance [210,211,212,213,214]
Production never stops, because turnover is fast within hours, glutathione is used, exported, or broken down, and must be made again
Chiu et al
Step 2: Enter Bacteriostatic Water Volume
However, spot urine samples are in general of limited value for calculating the average daily excretion, particularly for compounds with half-lives of a few hours (Warth et al
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