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doi: 10.1073/pnas.1403438111 97 TanLGurbaniDWeisbergELHunterJCLiLJonesDSet al

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J Neurol Sci 168 : 112115 (1999)

Critically, however, small amounts of ROS are necessary for healthy functioning as they are important intercellular signalling molecules: in large amounts though, ROS can be highly toxic because of their ability to react with sensitive intracellular biomolecules (DNA, proteins, lipids in bi-layer membranes, etc.) and so disrupt the vital biochemical pathways that sustain life [Morrell, 2010]