The shorter length means less tissue penetration but may not reach deep enough for people with thick subcutaneous layers
To mitigate these adverse effects, researchers have developed NAV-Gal, a prodrug of Navitoclax that is selectively activated by senescence-associated -galactosidase (SA--Gal) within senescent cells, thereby reducing off-target toxicity in non-senescent cells (Paez-Ribes et al., 2019)
Sheng J, Zhang W, Hassan AEA, Gan J, Soares AS, Geng S, et al
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