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Stack 3: comprehensive mood protocol For researchers seeking the most thorough multi-system approach, a comprehensive mood protocol might include elements targeting all five disrupted systems: neurotransmitter balance, HPA axis regulation, neuroinflammation, BDNF production, and gut-brain axis function

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Current Evidence Gaps No direct head-to-head randomized controlled trials comparing Retatrutide and Cagrilintide monotherapy exist in the published literature