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The sulfonamide 41 , like 23 (HA08) and 37 (HFI 419) increases spine density in primary cultures of hippocampal neurons but is unfortunately a too poor inhibitor of IRAP and is demonstrating a Ki value of 540 nM

Sections were stained with hematoxylin and eosin (H&E) in order to assess the necrotic areas

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In case of mutations affecting the function of the bile salt transporter, but especially when the FGF19-driven negative feedback pathway is defective, this leads to bile acid diarrhea type 2 (168)