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Song et al., 2025)

Persulfidation of the single reduced cysteine residue of human serum albumin caused an increase in reactivity towards both peroxynitrite and the disulfide 4,4-dithiodipyridine ( Mt AhpE caused an increase in the reactivity with 4,4-dithiodipyridine, which is not a substrate for the enzyme, but inhibited the reactivity towards the physiological substrates H 2 O 2 and peroxynitrite, when compared with the unmodified protein in the reduced state, due to alterations in the structure of the active site (Figure 2) ( FIGURE 2 Besides being nucleophiles, persulfides are also electrophiles, a property that is absent in thiols and in H 2 S/HS , but that is shared with polysulfides

T cell activation and retargeting using staphylococcal enterotoxin B and bispecfic antibody: an effective in vivo antitumor strategy

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Some autoimmune diseases can affect B12 metabolism or produce antibodies that interfere with B12 assays, potentially leading to falsely elevated readings