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Therefore, the innate immune response is initiated by distinct innate immune sensors: endosomally localized transmembrane Toll-like receptors (TLRs) and C-type lectin receptors (CLRs), and cytosolic nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) (DNA and RNA sensors)

In certain embodiments, any controlled-release otic formulation described herein increases the exposure of an active agent and increases the Area Under the Curve (AUC) in otic fluids (e.g., endolymph and/or perilymph) by about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, about 100%, or higher than 100%, compared to an otic formulation that is not a controlled-release otic formulation

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Safety and efficacy of stem cell therapy for treatment of neural damage in patients with multiple sclerosis