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It's generally safer for long-term use compared to chemical lightening agents

Ephedra: This herbal appetite suppressant can cause high blood pressure and erratic heart rate during surgery

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Important caveat: the evidence for these mechanisms and benefits is preclinical based on cell and animal studies

Inclusion and ethics statement All collaborators who fulfilled the authorship criteria defined by Nature Communications have been appropriately included as authors, recognizing their vital contributions to both the studys design and its implementation