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Endocrine Society [online], (2012)

Ostrovsky O, et al

Tirzepatide is not recommended for people with a family history of thyroid tumors or a family history of medullary thyroid carcinoma (MTC) and MEN2 syndrome (multiple endocrine neoplasia type 2 syndrome), as tirzepatide increases the potential risk of developing these tumors in rodents

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The IM route can be useful when oral supplements cause digestive issues or deliver inconsistent results