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Notably, PPAR alone is not sufficient to restore redox homeostasis and promote the M2 phenotype, as demonstrated by the exacerbation of neuroinflammatory cytokine production in NRF2-deficient mice challenged with LPS (Innamorato et al., 2008)

With respect to the oxidative balance, our results revealed that GSH production was greater in autumn than in the other seasons, whereas ROS production was greater in spring, as previously reported 45

These results approach the efficacy of Roux-en-Y gastric bypass surgery, which typically produces 25-30% weight loss at one year

Chronic inflammation can also cause other diseases