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These simulations show that administration of a depot intramuscular dose with a prolonged absorption phase is predicted to provide a means to administer a dosage of olanzapine that, on reaching steady-state conditions, provides an olanzapine exposure that is of the same magnitude as the exposure achieved for the equivalent oral daily dose

Comparing the two relies on separate studies with different designs, endpoints, and eras a structurally weaker basis than a single controlled comparison

62 The effector protein is typically pro-caspase-1, an inactive precursor of caspase-1

View source K Koike, Y Yamamoto, N Suzuki, R Yamazaki, C Yoshikawa, F Takano, et al

10.1016/j.ijwd.2018.09.004 81 GuarneriF