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This complex includes the nucleus tractus solitarius (NTS), the area postrema (AP), and the dorsal motor nucleus of the vagus nerve (DMV)

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This is also the highest dose that was studied in the SURPASS and SURMOUNT trials

2 expression is highly upregulated by exogenous GSH supplementation indicating a substrate-dependent regulatory mechanism ( Given the growing body of literature on CHAC proteins, a comprehensive overview of all published work is beyond the scope of this review