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It also found that their ratio (F/B) differed significantly between OVX and sham-operated mice, proposing it as a potential indicator of OP ( Firmicutes and Bacteroidetes influence bone metabolism by modulating the de novo synthesis of glutathione (GSH) via the key enzyme Gclc and by inhibiting mitochondrial biogenesis and ROS accumulation through the CREB pathway ( Changes of GM and intestine during aging and OP The composition and bacterial abundance of the GM exhibit distinct differences not only between young and old individuals but also between those with OP and healthy individuals