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Int J Clin Pract 2011, 65:684-690

In 2003, a clinical trial demonstrating prolonged survival of patients with metastatic colorectal cancer when chemotherapy was administrated in combination with humanized neutralizing antibodies targeting anti-vascular endothelial growth factor (VEGF) resulted in an FDA approval and provided proof-of-concept that anti-angiogenic therapy can be successfully used to treat cancer [4]

The study also reported improvements in cardiometabolic risk factors such as waist circumference, blood pressure, cholesterol levels, blood sugar markers, and inflammation

Vascular and Cardiovascular Research Senescent endothelial cells are strongly associated with vascular inflammation and reduced arterial elasticity

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