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This leads to both targeted anti-inflammatory effects at injury sites (where IRR expression is highest) and broader systemic modulation of inflammation, as seen in reduced circulating cytokine levels and improved outcomes in models of widespread conditions like diabetic complications, neuropathy, colitis, and autoimmune diseases, without broadly impairing overall immunity or stimulating red blood cell production

Specifically, to simulate the in vitro expansion for ACI, human chondrocytes were expanded to a population doubling level (PDL) 9 to represent chondrocytes ready for implantation

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Bleeding happens due to the formation of new skin and healing of the internal incisions made during surgery