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Additionally, certain variants in genes related to antioxidant response, such as the catalase (CAT) gene and the glutathione peroxidase (GPX) gene, have been associated with increased susceptibility to vitiligo.67,69,70 Furthermore, vitiligo has been associated with defective recycling of tetrahydrobiopterin (6BH4), essential for melanin formation, leading to an excess of 7BH4 and inhibition of phenylalanine hydroxylase (PAH)

doi: 10.1016/j.biopha.2021.111372

Importantly, most amino acid-altering mutations that reduce the overall activity of G6PD do so by decreasing protein stability, catalytic capacity or both

These data suggest that different interactors compete for binding by a hitherto unknown regulatory mechanism 55

2006 Severe vitamin B12 deficiency in an exclusively breastfed 5-month-old Italian infant born to a mother receiving multivitamin supplementation during pregnancy.[BMC Pediatr