Unlike growth factors peptides, which need carrier(s) addition, and are rapidly degraded in human gastric juice, BPC 157, as an antiulcer peptide, is native and resistant to human gastric juice exciding one day period (Sikiric et al., 1993
doi:10.3389/fphar.2022.871392
After supplementation with DHO or OA (the substrate and product of DHODH), the ferroptosis caused by GPX4 inhibition was attenuated and enhanced, respectively, and these effects were particularly significant in cancer cells with low GPX4 expression
Interestingly, the apoptotic effect of EA was observed only in leiomyoma cells without any effect on the peripheral blood mononuclear cells, which greatly reduces the possibility of causing an adverse effect (Kim et al., 2006)
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