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This response is shown to be an axonal response to the increased ATP demand of demyelinated axons mediated, at least partially, through activating transcription factor 3 (Kiryu-Seo et al., 2010)

The future of metabolic therapy likely lies not in single interventions but in carefully orchestrated multi-pathway approaches that address the complex, interconnected systems regulating appetite, metabolism, and body composition

10.1016/j.micpath.2020.104011 228 PetronekM

finally, in terms of limitations, it highlights the heterogeneity in evidence [e.g., variations in Omega-3 dosing across RCTs (65)] and population-specific biases [e.g., vitamin D studies focusing on IBD patients (169)]

Results were normalized to SRB