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These continuously generated electrophilic hydroperoxy-phospholipids are neutralized by a specific GSH-dependent peroxidase, glutathione peroxidase 4 (GPX4), which prevents them from damaging membranes and driving ferroptotic cell death (7, 8)

Large-scale data analyses indicate that approximately 40% of chemical substances exhibit hormetic characteristics, with evolutionary conservation across species, from bacteria to mammals 8

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The top three classes of metabolites with the highest relative abundances were amino acids and peptides (28.7%), lipids and lipid-like molecules (16.4%), and nucleosides and nucleotides (16.4%, Figure 2D)