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Up-regulation of the human gamma-glutamylcysteine synthetase regulatory subunit gene involves binding of Nrf-2 to an electrophile responsive element

Reduced Glutathione is in fact able to give up its hydrogen (H+), which acts as an acceptor of an electron (e-) coming from reactive oxygen molecules, that is, from free radicals

Several risk factors including age, hypertension, ischemic heart disease, diabetes, and chronic respiratory disease (Khanfar and Al Qaroot, 2020) increase the fatality rate (Ruan et al., 2020