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& Izad, M

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Vlassara H, Uribarri J (2014) Advanced Glycation End products (AGE) and diabetes: cause, effect, or both

Produced in the liver, glutathione is involved in: Neutralizing free radicals Detoxifying heavy metals and toxins Supporting immune function Regenerating other antioxidants like vitamins C and E Maintaining mitochondrial (energy-producing) function In skin health, glutathione works in three main ways: Reduces oxidative stress that causes inflammation and cellular damage Supports liver detoxification, which helps clear toxins and hormones that may contribute to acne Modulates melanin production by influencing the enzyme tyrosinase, potentially reducing hyperpigmentation When combined with vitamin C, glutathione becomes even more effective

In mice, the loss of JNK1 and JNK2 led to more severe age-related OA and ageing of cartilage and synovium (Loeser et al., 2020), an indication that JNK is a detrimental regulator of joint degeneration