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Schizophr Bull 1987

Sleep promotes antioxidant production including melatonin as well as the antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase (Gulec et al., 2012

564 HO-1 and GPX4 were downregulated due to Nrf2 defects in astrocytes, leading to increased mitochondrial fragmentation, DNA oxidation, and lipid peroxidation in mouse astrocytes, 564 suggesting that Nrf2 deficiency promotes ferroptosis in astrocytes in AD mice