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doi: 10.1155/2013/262039 40 ShinM.-K.Vzquez-RosaE.KohY.DharM.ChaubeyK.Cintrn-PrezC

Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity

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In the epidermis, ROS induce oxidative DNA lesionsincluding 8-hydroxy-2-deoxyguanosine (8-OHdG) formation, mitochondrial DNA damage, and telomere attritionactivating the p53-p21 pathway and leading keratinocytes toward cell cycle arrest or apoptosis [183, 184]