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Ages ranged from 11 to 15 years in one sample (Stice and Martinez 2005) to 46 years or older in another study (Janzon et al

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The methodology was also criticized because a normalization to either the total number of users or the frequency of drug use was not conducted, which might have biased the result toward the harms of opiate use 14 and may have underrepresented the harms of tobacco 15