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Localized swelling of the right ankle joint was observed, accompanied by mildly increased skin temperature and tenderness

Nie et al., 2024

Cystine then safely passes through the GI tract and blood plasma and is quickly converted into two LC molecules upon cell entry

The rationale for combining them is mechanistic complementarity (different signaling pathways, both implicated in tissue repair) and clinical anecdote in the peptide-therapy community not formal head-to-head or combination-vs-monotherapy data