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High concentrations of ROS in the ER lumen may also subsequently activate the ER calcium release channel type 1 inositol 1,4,5-trisphosphate receptor (IP3R1), leading to the leakage of calcium from the ER lumen into the cytoplasm

Wilson et al., 2016

Of all systems within the human body, it is one of the most strongly affected by microgravity ( 3.1.4

Research suggests that the ventromedial hypothalamus (VMH) plays a central role in leptin-induced glucose uptake in skeletal muscle, brown adipose tissue (BAT), and heart tissue

This is where the structural innovation of S-Acetyl Glutathione (S-A-GSH) completely changes the therapeutic landscape