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Stimulating leptin signaling Recent preclinical evidence has shown that coadministration of amylin with leptin improves leptin-mediated STAT3 signaling in the ventromedial hypothalamus of rats with diet-induced obesity [47]

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A peer-reviewed study in the Journal of Endocrinology confirming that AOD9604 produces lipolysis and increases fat oxidation in obese mice via the beta-adrenergic pathway, with effects comparable to full-length HGH but without the insulin-disrupting side effects provided early mechanistic validation that informed the human trials